Semi-Annual Review of Lifeline Products Featured in 2021
2021 has been a monumental year for science with the landmark approvals of not one, but two COVID-19 vaccines in the US with many other candidates in the clinical pipeline.…
Impact of E-Cigarette Smoke on Cardiovascular Function
Cigarette smoking is one of the primary risk factors for cardiovascular disease (CVD). In fact, the American Heart Association reports that smoking-related diseases are responsible for > 440,000 deaths in…
Drug Repurposing to Treat COVID-19 Induced Lung Injury
The rapid spread of COVID-19 during the global pandemic has led many scientists and researchers to look towards repurposing existing FDA-approved drugs, outside the scope of their originally designated purposes,…
Obesity-Driven Increase in Endometrial Cancer Risk
Endometrial cancer (EC), sometimes called uterine cancer, begins in the layer of cells that form the lining (endometrium) of the uterus and is the most common cancer of the female…
The Role of SO2 in Pulmonary Vascular Remodeling
Chronic obstructive pulmonary disease (COPD) is the third most common cause of death in the United States. The incidence of aging and age-related cardiopulmonary diseases like COPD has become more…
Circadian Clock Protein BMAL1 Protect Against UVB Damage
The skin is the largest organ of the human body composed of the epidermis (upper or outer layer) and the dermis (lower or inner layer). The epidermis, which is made…
New Therapeutic Strategies for Adult T Cell Leukemia/Lymphoma (ATLL)
Leukemia, lymphoma, and myeloma are the most prevalent types of blood/bone marrow cancers in the US today. Leukemia accounted for 34% (60,000 individuals) of all blood cancers in 2020 and…
Half Year Recap 2021 – Lifeline Products in Action
It’s time for our mid-year review, how quickly it has passed! In the first half of 2021, we covered a lot of research and industry insight on COVID-19 and SARS-CoV-2…
Effects of Hyperbaric Oxygen on Wound Healing
Fibroblasts have an important structural role in the body’s tissues, responsible for depositing the extracellular matrix (ECM) and collagen necessary for connective tissue support and tissue repair. In the context…
Endothelium Barrier Function Helps Mitigate Metastasis
Cancer Biology: Learnings from Transcriptomics Analysis Human Umbilical Vein Endothelial Cells, or HUVECs as they are more commonly known, are widely utilized as an in vitro model system for studying…
MSC-EVs Modulate Airway Epithelial Cell Function
Mesenchymal stem cells (MSCs) are multipotent adult stem cells that give rise to cells of the skeletal system including cartilage (chondrocytes), bone (osteoblasts), and fat cells (adipocytes). MSCs play an…
3D Models in Prostate and Male Reproductive Research
Robust 3D Models are Important Research Tools Two-dimensional (2D) cell culture is the backbone of many research programs for a number of reasons – they are historically well-established, simple and…
Cardiometabolic Risk Factors and COVID-19
In keeping with the theme of last week’s blog on the development of a high throughput preclinical airway model for testing anti-viral therapeutics against influenza and coronaviruses, we will be…
Bronchial/Tracheal Epithelial Cells Used in New Airway Model to Evaluate Therapeutics
A Pre-clinical Model to Evaluate Therapeutics for Respiratory Infections The current COVID-19 pandemic has highlighted the need for a robust pre-clinical model of the respiratory tract that can allow researchers…
Promising New Candidate to Treat Influenza Infections
A Better Drug Candidate to Treat Influenza Infections Influenza viruses are responsible for over 600,000 deaths globally and have a huge impact on human health and productivity. However, the moderate…
Mechanisms Driving Inflammation in Psoriasis
The Role of IL-22/PLCε Signaling in Psoriasis The outermost layer of the skin is the epidermis, which primarily functions as a protective mechanical barrier preventing the entry of harmful pathogens.…
Long Term Health Impact of COVID-19 Patients
Since the emergence of the COVID-19 pandemic, the impact of the virus on the heart has become more pervasive prompting the Journal of the American College of Cardiology to issue…
The Role of Monocytes in Diabetic Retinopathy Pathogenesis
Peripheral blood cells are the circulating cellular components of blood consisting of red blood cells (erythrocytes), white blood cells (leukocytes), and platelets. White blood cells make up ~1% of all blood cells and each subpopulation has a specialized…
Modelling Respiratory Damage Caused by Air Pollution
Smooth Muscle & Skeletal Muscle Satellite Cells The lungs are the largest organ in the body primarily responsible for respiration, the exchange of oxygen and carbon dioxide that is essential…
Myocardial Injury in Severe COVID-19 Infections
The rapid emergence and spread of COVID-19 caused by SAR-CoV-2 has put a heavy burden on scientists and clinicians to try to figure out, in real-time, the direct and indirect…